根据首字母提示填词：

1．It's bad manners to speak loudly in p_________.

2．To my great d________, my father failed to buy me a new computer on my birthday.

3．The dentist won't see you unless you have an a_______ with him ahead of time.

4．Her teaching experience gave her a big a________ over the other applicants for the job.

5．Scientists have d________ a new virus. It is very important to medical research.