________time went on, the people in the area came to realize how seriously the environment had

been polluted.[ ]

A. As  

B. With

C. When  

D. While

男，48岁，颈增粗20年，近一年消瘦10kg，并有心悸。体检发现双侧甲状腺多个结节。基础代谢率+31%，2小时内甲状腺摄碘29%

最可能的诊断是（）

A.单纯性甲状腺肿

B.结节性甲状腺肿

C.原发性甲亢

D.继发性甲亢

E.甲状腺肿瘤