[案例] 患者王某，男，56岁，农民。因“左侧额部起斑疹、渐增大6个月余”就诊。
患者半年前无明显诱因于左侧额部突然出现一绿豆大小的暗红色斑疹，边缘略隆起，表面覆着少许细小白色鳞屑，无痛痒，未予重视。以后皮疹边缘渐向周围蔓延、扩大至甲盖大小，颜色变成灰棕色，且日晒或局部冷热刺激后有瘙痒感。自行外搽0.1%维A酸乳膏，皮疹不见好转。尤其近2个月来，局部皮疹已增大至鸡蛋大小，影响了患者容貌。发病来，患者无长期低热、无头痛头晕、无全身关节酸痛等症状，体重无明显减轻。既往史和个人史无特殊。否认家族遗传病史及类似病史。
本病确诊后最佳的治疗方法是（）
A．外用5%氟脲嘧啶软膏
B．液氮冷冻
C．CO2激光
D．微波
E．直线加速器电子束放射治疗
F．手术切除
参考答案：F
解析：
Bowen病的最佳治疗方法为手术切除，因少数病例皮损可有侵袭性生长。皮损较大者手术后可植皮。物理疗法(液氮冷冻、CO2激光或微波)或外用细胞毒性药物制剂对单个、较小的皮损亦有效，缺点是治疗后易复发，难以达到根治疗效。
Michael Scofield has won fans all over the world. The star of the hit show Prison Break is kind, clever and good-looking. But what about the man the character? Wentworth Miller, the 35-year-old actor who plays Scofield, is a hard guy to figure out. He does not come from a traditional background and doesn’t a traditional path. Miller didn’t take a road to fame. He graduated from Princeton University in 1995 with a degree in English, not a degree in or film. He didn’t even act when he was in college. His only experience was in his university’s well-known singing group. Yet, at graduation, Miller still decided to make the to Hollywood. Miller has always been . Although he is American, he was born in Britain when his father was studying there. His family background is a of cultures. “My father is black and my mother is white. That means I have always been caught in the middle. I could be one, which can make you feel out of place,” Miller says. Following his unusual path, Miller did not start trying out for films when he got to Hollywood. , he worked as a production assistant. Working on production side, he learned a lot about what makes a good . In 2002, Miller played a role in the drama Dinotopia. He starred as a shy man. The producers his performance when they were making Prison Break two years later.
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