-- Did you find the small village yesterday?

-- Yes, without any difficulty, for it has ______ changed over years.

A．hardly

B．greatly

C．clearly

D．nearly

属于乙酰胆碱酯酶和丁酰胆碱酯酶双重抑制剂的药物是（）

A.多奈哌齐

B.卡巴拉汀

C.加兰他敏

D.石杉碱甲