问题 单项选择题

主要不良反应为锥体外系反应的是()

A.甲氧氯普胺

B.多潘立酮

C.西沙必利

D.莫沙必利

E.伊托必利

答案

参考答案:A

解析:本组题考查促胃肠动力药的作用特点及不良反应。促胃肠动力药主要包括3大类:(1)多巴胺D受体阻断剂,代表药物是甲氧氯普胺,具有中枢和外周多巴胺D受体阻断作用,其主要不良反应是由于作用于中枢多巴胺受体而导致的嗜睡、倦怠等锥体外系反应。(2)外周性多巴胺D受体阻断剂,代表药物是多潘立酮,选择性作用于外周,对中枢多巴胺受体无作用,神经系统副作用罕见。(3)5-羟色胺受体激动剂,代表药物有西沙必利、莫沙必利,其中西沙必利可导致Q-T间期延长、室性心律失常等心脏毒性,已逐渐被临床淘汰,目前应用较多的是莫沙必利,是一种高效选择性5-HT受体激动剂,心律失常的副作用罕见。故答案选CABDA。

单项选择题
问答题

For five years I have maintained our nation’s solid commitment to scientific research and technological development, because I believe they’re essential to our nation’s economic growth and to building the right kind of bridge to the 21st century. The balanced budget I will submit in just a few weeks to Congress reflects this continued commitment. And, in my upcoming State of the Union Address, I’ll talk more about what we arc doing to keep America on the cutting edge of the scientific and technological advancements that are driving our new global economy. Still, it’s good to remember that scientific advancement does not occur in a moral vacuum. Technological developments divorced from values will not bring us one step closer to meeting the challenges or reaping the benefits of the 21st century. This week, like many Americans, I learned the profoundly troubling news that a member of the scientific community is actually laying plans to clone a human being. Personally, I believe that human cloning raises deep concerns, given our cherished concepts of faith and humanity. Beyond that, however, we know there is virtually unanimous consensus in the scientific and medical communities that attempting to use these cloning techniques to actually clone a human being is untested, unsafe and morally unacceptable. We must continue to maintain our deep commitment to scientific research and technological development. But when it comes to a discovery like cloning, we must move with caution, care. and deep concern about the impact of our actions. That is why I banned the use of federal funds for cloning human beings while we study the risks and responsibilities of such a possibility. And that’s why I sent legislation to Congress last June that would ban the cloning of human beings for at least five years while preserving our ability to use the morally and medically acceptable applications of cloning technology. Unfortunately, Congress has not yet acted on this legislation. Yet, it’s now clearer than ever the legislation is exactly what is needed. The vast majority of scientists and physicians in the private sector have refrained from using these techniques improperly, and have risen up to condemn any plans to do so. But we know it’s possible for some to ignore the consensus of their colleagues and proceed without regard to our common values. So today, again, I call on Congress to act now to make it illegal for anyone to clone a human being.