下列对药物稳定性表述正确的是（）
A.硫酸阿托品因溶液的稳定性受温度影响较大，而与溶液的pH值无关
B.零级反应的反应速度与反应物浓度有关
C.药物的降解不受溶剂的影响
D.表面活性剂不能影响药物的稳定性
E.光能激发氧化反应，药物分子受光线活化而产生分解，从而加速药物的分解。此种反应叫光化学降解，其反应速度与系统的温度无关
参考答案：E
解析：硫酸阿托品是酯类药物，常受H+和OH-催化水解，所以酯类药物的水解速度主要由pH值决定。零级反应因为反应物是在过饱和的情况下反应，所以其反应速度与反应物浓度无关。溶剂、表面活性剂是影响药物稳定性的处方因素，影响药物的降解。光能激发氧化反应，药物分子受光线活化而产生分解，光线波长越短，能量越大，因此紫外线更易激发反应，从而加速药物的分解。此种反应叫光化学降解，其反应速度与系统的温度无关。所以答案为E。
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| Sumo wrestlers (相扑选手) are usually big, heavy men. The biggest sumo wrestler of all the time is Koni-shiki, who now 1 about 230 kg. Born in Hawaii, he was 2 a big boy. When he was a teenager, some people 3 he go to Japan and become a sumo wrestler. Although he took their advice, at first it was a 4 life. "I had to clean the toilets and 5 the rubbish (垃圾)," Konishiki remembered, "I knew I had to 6 to life in Japan. I said to myself, 'I 7 learn Japanese.' Soon I could 8 it quite well." Konishiki's career started 9 , and he was soon upgraded to a higher rank. But despite his 10 he soon had health problems. The doctors told him that he should 11 some weight. "I started dieting. I 12 to do it. But I did it too 13 ," he said, "I lost some of my strength, too." He lost a lot of fights, and then his parents got 14 in a car crash. "I must go and 15 them," he thought. Though it was only three days 16 a big tournament (锦标赛), he flew back to Hawaii. Despite his 17 , they were not badly injured. When he returned, he knew that he had to do well. The newspapers said, "Konishiki must win, 18 he will go down in rank." Though he had many problems, Konishiki won 14 of his 15 fights, and won the Emperor's Cup. He was so 19 that he cried. "You ought not to show your feelings," he said, "but I couldn't 20 it." | |||
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