The news came as no surprise to me . I ____ for some time that the factory was going to shut down .

A．knew

B．know

C．have known

D． had known

主治胸痹，胸中闷痛，甚至胸痛彻背，喘息咳唾，短气，舌苔白腻，脉沉弦者宜选用（）

A.瓜蒌薤白白酒汤

B.瓜蒌薤白半夏汤

C.枳实薤白桂枝汤

D.枳实消痞丸

E.半夏厚朴汤