关于根除Hp治疗，下列说法正确的是（）。

A.根除Hp可选用三联疗法和四联疗法，其中必须含有铋剂

B.雷尼替丁铋盐复方制剂（RBC.可代替PPI用于根除Hp

C.青年患者可安全使用PPI+阿莫西林+左氧氟沙星方案

D.初治失败的患者宜行Hp药敏试验

E.胶体次枸橼酸铋的常用剂量为480mg/d

The nurse discusses discharge plan with the parents of a child following a sickle cell crisis. Which of the following would the nurse emphasize the need to seek prompt health care

A．Headaches and nausea.

B．Fatigue and lassitude.

C．Skin rash and itching.

D．Sore throat and fever.