患者女，47岁。急性黄疸型肝炎患者，经治疗无效，症状渐渐加重。诊断重型肝炎最主要的依据是（）

A.血清胆红素明显升高

B.血小板降低

C.凝血酶原活动度小于40%

D.肝细胞大量减少

E.白细胞的高低

The settlement is home to nearly 1,000 people, many of()left their village homes for a better life in the city.

A. whom

B. them

C. which

D. those