患者，女性，39岁。因甲状腺功能亢进服用丙硫氧嘧啶治疗，2个月后出现药物反应。下列需停药观察的重要指征是（）。

A.出现皮疹

B.中性粒细胞<1.5×10⁹/L

C.突眼加重

D.头晕、乏力

E.胃肠道反应

Using this kind of hybrid, farmers are producing harvests _____ before. [ ]

A. twice as many as

B. twice as large as

C. as twice large as

D. as twice many as