—_____ his friend work?

—He works in a shoe factory.[ ]

A. What does                

B. How does                 

C. Where does            

D. When does

链球菌感染后急性肾小球肾炎与IgA肾病的根本不同是（）

A.链球菌感染史

B.病程长短

C.起病缓急

D.肾脏组织病变

E.发热与否