For forty years Jane has been ___________ about making the rest of the world understand and respect the life of these animals.

A．generous

B．obvious

C．outspoken

D．subjective

根据《药品注册管理办法》，按照药品补充申请的是（）

A.对已上市药品改变剂型的注册申请

B.对已上市药品改变给药途径的注册申请

C.对已上市药品增加新适应症的注册申请

D.对已上市药品增加原批准事项的注册申请

E.对境外生产的药品在中国境内上市销售的注册申请