滴眼剂滴眼后在受体部位的可利用度与下列哪个因素无关（）

A.结膜囊内药物动力学

B.滴眼剂的用药频率

C.药物对角膜的通透性

D.药物在眼内的清除率

E.药物在眼内的分布

After cleaning the skin, she softly __________ an appropriate amount of face-cream to the face and neck, and then gently massaged until it was fully absorbed.[ ]

A. pressed

B. poured

C. processed

D. applied