Sam has been appointed _______ manager of the engineering department to take ____ place of George.

A．/,/

B．the; the

C．the,/

D．/, the

患者，女性，60岁，多年患结节性甲状腺肿，近2周右侧叶一结节明显增大，质硬，内有砂粒样钙化点，同侧颈淋巴结肿大。

首先考虑诊断是以下哪一个（）。

A.结节癌变

B.结节囊性变

C.结节腺瘤样变

D.结节继续增大

E.结节钙化