患儿男性，12岁，发热、皮疹2个月余。实验室检查示红细胞沉降率增快，抗中性粒细胞胞浆抗体（ANCA）阳性，疑诊为血管性疾病。

胞浆型ANCA是下列哪种疾病的标志性抗体（）

A.过敏性紫癜

B.坏死性新月体性肾炎

C.Wegener肉芽肿

D.溃疡性结肠炎

E.自身免疫性肝炎

The voyages of travellers before the 17th century show that they were not _____ the sea even

though they didn't have modern navigational aids.                                                                                                                                    [ ]

A. at the expense of

B. at the risk of

C. in the way of

D. at the mercy of