采用溶剂法分离水溶性生物碱时，常用的溶剂有()

A．乙醇

B．正丁醇

C．异戊醇

D．水

E．丙酮

Great changes ___ in my hometown and a lot of factories _______.

A．have been taken place , are being set up

B．have taken place , have been set up

C．are taken place , had been set up

D．had taken place , will be set up