问题 问答题 简答题

如何将内源性孕激素黄体酮进行结构改造成具有口服活性的孕激素。

答案

参考答案:

对黄体酮的药物代谢研究发现,孕酮类化合物失活的主要途径是6位羟基化,16位和17位氧化,或3,20-二酮被还原成二醇。因此对黄体酮的结构修饰主要是在及C-16位上引入羟基及C-6用烷基、卤素等进行取代及引入△6双键,如醋酸甲地孕酮、等是口服孕激素。

阅读理解

阅读理解。

     请认真阅读下列短文,并根据所读内容在文章后表格中的空格里填入最恰当的单词。注意:每空

格1个单词。

     Quality after-school programs are designed to improve academic performance, decrease youth crimes and

other high-risk behaviors, and help young people grow into healthy, successful adults.

     The effect of quality after-school programs on academic performance is clear. Studies show that students

who take part in such programs show better work habits, higher rates of homework completion, improved

grades, and higher scores on achievement tests. They also have fewer absences and are less likely to blame.

After-school programs also influence high-risk teen behavior. Various studies show decreased rates of crime,

drug use, and teen sex among youth who join in well-run after-school programs when compared to similar

youth who do not. Finally, after-school programs play an important role in supporting the following fields of

development: physical development, mental development and social development. Thus, one can safely say that

after-school programming is an effective method to help young people become contributing members of society.

     Although there is enough proof from both small and large assessments that after-school programs can make

a positive difference, it is important to note that not all programs are equal. First, dosage (时量) matters-young

people who attend the most hours over the most years benefit more than members who attend less often or

over a shorter period of time. Next, after-school programs make bigger difference for those students who need

help most and have the fewest choices. Finally, program qualities matter. After-school programs work best

when they create unique opportunities for youth. They should provide opportunities for positive relationships,

skill building, meaningful involvement (参与), expression, suggestion, service, and work. Staff characteristics

make an important difference in the quality of a program. The adults should treat youth as partners, create safe

and fair environments, encourage personalized (个性化的) involvement, and actively create learning

opportunities. In short, although after-school programs have promising future, how they are designed and run

matters.

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