Cushing病的发生可由于（）

A.垂体微腺瘤

B.垂体大腺瘤

C.肾上腺皮质腺瘤

D.肾上腺皮质癌（2004）

All the efforts finally ________ in 2007, when the band’s album won lots of awards.

A．set off

B．paid off

C．took off

D．ran off