Great changes __ in the city in the past 20 years, and a lot of factories ____.

A．have been taken place; have been set up

B．have taken place; have set up

C．have taken place; have been set up

D．were taken place; were set up

患者女性，22岁，因“腋臭”来诊。患者平时只有在活动后或夏季才能被旁人闻到腋下异味，要求治疗。查体：腋下轻度异味，出汗试验中度。

肉毒素治疗腋臭的机制是（）

A.关闭汗腺出口

B.脱毛后毛孔堵塞

C.抑制汗腺分泌

D.抑制细菌繁殖

E.抑制皮脂腺分泌