帕金森病患者出现肌紧张过强而运动过少的症状是由于（）

A.前庭小脑神经元病变

B.红核神经元病变

C.新纹状体γ-氨基丁酸能中间神经元病变

D.黑质一纹状体多巴胺递质系统功能受损

E.新纹状体胆碱能中间神经元病变

Without your timely advice and help, we______so much.

A．will never achieve

B．could hardly achieve

C．can't have achieved

D．wouldn't have achieved