You can ask him again if you like, but it won't make any ______-he'll still say no.[ ]

A. mistake 

B. decision

C. contribution  

D. difference

酒后驾车而发生重大车祸，造成伤亡事件，其主要原因是[ ]

A．发生了慢性的酒精中毒

B．酒精增加了肝脏负担

C．酒精使心肝血管受损

D．酒精影响了大脑的控制能力，导致行为失控