If water becomes increasingly scarce in decades _______, water shortage will become a hot issue all over the world.  [ ]

A. coming

B. having come

C. to come  

D. to be coming

是指新药申请、仿制药申请或进口药申请经批准后，改变、增加或者取消原批准事项或者内容的注册申请（）

A.新药申请

B.仿制药申请

C.进口药申请

D.补充申请

E.补充药申请