— I'm sorry, I shouldn't have been so rude to you.  

— You ______ your temper but that's OK. [ ]

A. have lost

B. had lost

C. did lose          

D. were losing

女性，65岁，冠心病心绞痛史8年，无高血压史，夜间突发心前区疼痛8小时入院。入院时血压为150/90mmHg（20/12kPa），经心电图检查，诊断急性前壁心肌梗死

此时最具特征性的实验室改变是（）

A.血清LDH水平增高

B.血清GOT（AST）水平增高

C.血清GPT（ALT）水平增高

D.血清CK-MB水平增高

E.血清肌红蛋白下降