Some lawyers have long called for changes to these laws which they think are ___ in the 21 st Century.

A．in place

B．on the way

C．by the way

D．out of place

下列哪项是加剧肾小球硬化的主要因素（）

A.三高现象

B.补体

C.血小板

D.中性粒细胞

E.内皮细胞