采用下列何种措施可避免细菌产生耐药性（）。

A.合理使用抗菌药物

B.联合用药

C.轮换用药

D.足够的剂量与疗程

E.开发新的抗菌药物

A survey of China's citizens found that some smokers are unwilling to kick the habit because they aren't fully aware ________ the harm it does to health.