问题 多项选择题

为增加糖皮质激素的抗炎活性,降低钠潴留作用可进行的工作

A.C1引入双键

B.C9α引入氟

C.C16α引入甲基

D.C6α引入CH3( * * 示)或C1

E.C16α、C16β引入OH

答案

参考答案:A,B,C,D

解析:糖皮质激素的构效关系指出;引入1位双键使抗炎活性增强,但钠潴留作用不变;9α位引入氟原子,抗炎作用增强,盐代谢作用增强更显著:6位引入氟原子与9α位引入氟原子产生同样效果且可阻滞C6-氧化失活;16位引入羟基或甲基可以消除在9α位引入氟原子所致的钠潴留作用。 C16甲基使17α-羟基及C20-羰基在血浆中稳定性增加,抗感染活性增强;16α-甲基转换成β-甲基,活性有所升高。

阅读理解

A few years ago, I moved into a new house in Los Angeles. Soon after, a family moved in next door. It wasn’t the best of times for me. I had just divorced(离婚) from my second wife, and I wasn’t working. I’d come home each day and sit by myself in the backyard. One night, I heard someone from the yard next door, “Tom ! How are you, Tom? ” 

I couldn’t see anybody through the trees, but I answered, “I’ m good.”

“Good!” said the voice.

“What’s your name?” I asked.

“Eric.” Then I heard someone say, “Eric, don’t bother him.”

“Okay!” Eric said. “Talk to you tomorrow!”                                                                           

Months later, on Halloween, we finally met face to face. Eric came to the door dressed like a rap star. We became friends. We’d hang out in our yards, and Eric, who was almost 17 at the time and look liked a 13-year-old, would tell me his ideas and dreams. Eric’s dad, Alec Gores, is a billionaire(亿万富翁), the head of Gores Technology Group.

One day, Alec called me and said, “I know you are an actor. My son’s an actor, too. And he’s very good. I want you to write a movie for him. He wants to do something like True lies.” That’s the movie I made in 1994. His father has given Eric the great gif of confidence. He believes he can do anything he wants. He also offered to fund the movie. And that’s how The Kid & I, which opens in November, began.

Well, I really have to say that opportunity(机会)lies anywhere.

小题1:What do we learn about the writer when he had just moved into his new house in Los Angele?

A.He often came back very late.

B.He was working in the city at that time.

C.He and his second wife had just gotten divorced.

D.He often talks with others in the backyard.小题2:The writer of this passage is a(an)        .  

A.teacher

B.actor

C.singer

D.doctor小题3:What do we learn about Eric from the passage?

A.He lives alone with his father.

B.He has a very rich father

C.He often feels very lonely.

D.He is a rap star.小题4:The second last paragraph(倒数第二段)mainly tells us        .

A.how The Kid & I began

B.the roles in The Kid & I

C.how the writer met Eric’s father

D.what The Kid & I is about小题5:From his experience in Los Angeles, the writer learnt that        . 

A.where there is a will, there is a way.

B.one should always learn from the past.

C.one can find opportunity anywhere.

D.life can always be better.

单项选择题