患者男，59岁。吸烟30年，每日20支，每遇秋冬咳嗽15年，到呼吸科门诊咨询是否有COPD。

慢性阻塞性肺病进展中最先发生异常的实验室检查为（）

A.肺泡一动脉氧分压差

B.胸部X线片

C.最大呼气流速

D.FEV₁

E.用力肺活量时的最大呼气中期流量（MEF25%～75%）

—The patient looks much better.________ is it that has made him ________ he is today?

—Perhaps the special medicine and his family's patient care.

A．What；that

B．That；that

C．What；what

D．What；which