与局麻药吸收有关的因素（）

A.注药部位

B.注药剂量

C.局部组织血液灌流

D.药物与组织结合

E.加用血管收缩药

Mark Williamson is "bearish" on ABC Manufacturing Company. Williamson is so convinced that ABC is overpriced, two weeks ago, he shorted 100000 shares. Today, Williamson is "surfing" several popular investment bulletin boards on the internet and posting false derogatory comments about company management. According to Standard Ⅱ (B), Market Manipulation, Williamson has engaged in:（）

A. transaction-based manipulation, but not information-based manipulation. 

B. both transaction-based manipulation and information-based manipulation. 

C. information-based manipulation, but not transaction-based manipulation.