—What about going out this evening?

—Oh, I don't know. I've got a bit of a headache. And,         John’s coming to see me, so I ought to stay in.

A．though

B．therefore

C．however

D．anyway

患者女性，54岁。慢性肾炎病史20余年，头痛、食欲减退、恶心1个月。查体：血压190／110mmHg，重度贫血貌，双下肺可闻及湿啰音，心界向左下扩大，主动脉瓣区可闻及2／6级收缩期吹风样杂音，腹部移动性浊音阳性，双下肢水肿。初步诊断（）

A.急进性肾炎并急性肾衰竭

B.慢性肾炎并急性肾功能不全

C.高血压肾病并急性肾功能不全

D.慢性肾炎并慢性肾衰竭

E.高血压肾病并慢性肾衰竭