问题 单项选择题

女,20岁。因掌跖皮肤出现红斑、增厚18年伴部分末端指(趾)节畸形、溃疡8年余。系统查体未见明显异常。皮肤科检查:手部见弥漫性红斑、增厚伴手指畸形外观,中指伸侧有蜂窝状凹陷。双手拇指关节处见海星状角化。双足跖弥漫性角化增厚并有皲裂、糜烂伴恶臭,角化增厚边缘附黄色厚鳞屑,第一趾和第二趾可见甲变形、甲分离和混浊。组织病理示:表皮明显角化过度,颗粒层、棘层肥厚,表皮突延长,真皮可见少量炎性细胞浸润,皮下脂肪组织大致正常。

该病是由哪种蛋白的基因突变所引起

A.角蛋白1
B.连接蛋白26
C.角蛋白9
D.跨膜蛋白
E.桥粒斑蛋白

答案

参考答案:B

解析: 该病是由连接蛋白26基因突变所致。

填空题
单项选择题

Robert Moody, 52, is an experienced police officer. Much of his work involves dealing with (16) and gang (团伙)problems in the schools of his community. Knowing that many kids often (17) trouble, he decided to do something about it. So in 1991 he began to invite small groups of kids to go fishing with him on his day (18) .

Those fun trips had a(n) (19) impact. A chance encounter in 2000 proved that. One day, (20) working security at a school basketball game, Moody noticed two young guys (21) . He sensed trouble between them. (22) one of them headed toward Moody and gave him a hug. "I (23) you. You took me (24) when I was in fifth grade. That was one of the (25) days of my life. "

Deeply touched by the boy’ s word, Moody decided to create a foundation (基金会)that (26) teenagers to the basics of fishing in camping programs. "As a policeman, I saw (27) there was violence, drugs were always behind it. They have a damaging (28) on the kids," says Moody.

By turning kids on to fishing, he (29) to present an alternative way of life, "When you’ re sitting there waiting for a (30) ," he says, "you can’t help but talk to each other, and such (31) can be pretty deep. "

"Talking about drugs helped prepare me for the peer(同龄人)pressures in high school," says Michelle, 17, who (32) the first program. "And I was able to help my little brother (33) drugs. "

Moody faces (34) in three years, when he hopes to run the foundation full-time. "I’ m living a happy life and I have a responsibility to my (35) to give back," Moody says. "If I teach a kid to

fish today, he can teach his brother to fish tomorrow. \

22().

A. Slowly

B. Suddenly

C. Finally

D. Secretly