患者男，78岁，已婚，因“体检发现血PSA＞200ng/ml半年”来诊。直肠指检：前列腺可触及质硬结节，无压痛。经直肠前列腺B型超声：前列腺左侧可见低回声结节，内可见血流。盆腔MRI：前列腺可见突出包膜，精囊角消失。ECT：髂骨可见多处转移灶。前列腺穿刺活检：前列腺癌，Gleason评分主要生长方式5分，次要生长方式4分。住院后给予内分泌治疗（诺雷德、康士德）后血PSA下降，后血PSA再次升高。

临床工作中前列腺穿刺活检的指征一般包括（）

A.直肠指诊发现结节，不管血清PSA情况

B.前列腺B型超声发现前列腺内低回声结节或前列腺MRI发现异常信号

C.血清PSA4～10ng/ml，f/tPSA正常或PSAD正常

D.直肠指诊未发现结节，血清PSA＞4ng/ml

E.血清PSA4～10ng/ml，f/tPSA异常或PSAD异常

F.血清PSA＞10ng/ml

Turkey’s Bodrum peninsula is different. The tourist boom in this part of the world (1) turned some small villages into resorts yet left neighbouring beaches undisturbed, making it quite (2) southern France or the Spanish Coasts where few stretches of coastline are undevelopeD．
The (3) for this happy set of circumstances is simple. For thousands of years, travel here (4) easier by boat than by lanD．So when mass tourism arrived in the (5) 1980s, there was no coast road for ribbon development to follow. So the peninsula, just (6) hour from Bodrum airport, has not become one long littoral of resort.
The building (7) new hotels has mainly been confined to places easily reached by then relatively (8) roads. Such ease of access has made Gumbet, near Bodrum, a busy resort, while the little fishing village of Gumusluk, 12 miles further west and only recently reachable by (9) , remains tranquil and undisturbeD．
It’s worth thinking carefully about location when planning a family (10) on the peninsulA．Choose a place that is centrally located, preferably out of earshot (11) Bodrum town’s "lively"—which means nosy—nightlife, and you can then use (12) area’s comfortably small scale to your advantage. Today’s new roads mean most places can (13) reached in under an hour by taxi or the ubiquitous dolmus-minibus.
The (14) of facilities at the Tamarisk Beach Hotel near the small village of Ortakent makes (15) a good base. The family-run hotel—rooms and suites are in two-storey buildings (16) by palm trees and flowers in terracotta pots—sits above its own sandy (17) beach, shaded by tamarisk trees and sheltered by nearby islands.
The hotel is (18) child-friendly, too. Children, from infants up to young teenagers, can take part in a (19) of games and activities that include tuition in windsurfing, dinghy (20) catamaran sailing.