— I'm sorry I didn't make it to your party last night.  

—  ____. I know you are busy these days.   [ ]

A. Of course.      

B. No kidding.  

C. That's all right.    

D. Don't mention it.

患者，男，62岁，患风湿性心瓣膜病10余年，近1年活动后易发生心悸、气短，近半个月常由体力活动诱发心前区憋闷感，休息后缓解，昨日于运动中发生晕厥，急诊入院。根据该患者的临床表现，其可能的瓣膜病变是（）

A.二尖瓣狭窄

B.二尖瓣关闭不全

C.二尖瓣狭窄合并关闭不全

D.主动脉瓣狭窄

E.主动脉瓣关闭不全