—Your house looks a real mess, Tracey.

—________? There's no one who knows it except you.[ ]

A. So what  

B. What for

C. You what  

D. Now what

高血压患者出现以下哪项表现，能最早提示心功能由代偿期进入失代偿阶段（）

A.心尖区第一心音降低

B.肺动脉瓣第二音亢进

C.室性期前收缩

D.劳力性呼吸困难

E.夜间阵发性呼吸困难