问题 多项选择题 案例分析题

美国上市的产品Covera-HS,其主药为盐酸维拉帕米,片芯药物层选用聚氧乙烯(分子量30万),聚乙烯吡咯烷酮(PVP)K-29-32等作促渗剂;渗透物质层则包括聚氧乙烯(分子量700万),氯化钠,羟丙基甲基纤维素E-5(HPMCE-5)等。外层包衣用醋酸纤维素、HPMC和聚乙烯二醇3350(PEG3350)。用激光在靠近药物层的半透膜上打释药小孔。这样制备的维拉帕米定时控释片在服药后间隔特定的时间(5小时)以零级形式释放药物。Covera-HS晚上临睡前服用,次日清晨可释放出一个脉冲剂量的药物,符合该病节律变化的需要。

关于口服定位释药系统,叙述正确的是()

A.改善药物在胃肠道的吸收

B.治疗胃肠道的局部疾病

C.加大剂量,增强疗效

D.提高疗效,降低全身性不良反应

E.改善缓释、控释制剂因受胃肠运动影响而造成的药物吸收不完全、个体差异大等现象

F.可分为胃定位释药系统,小肠定位释药系统和结肠定位释药系统

答案

参考答案:A, B, D, E, F

选择题
阅读理解

阅读理解

     Our daughter Megan is severely disabled.My wife and I cared for her over twenty years at

home.Two years ago, we sent Megan to a nearby nursing home where we thought she could be

taken care of and become happier.

     A few weeks after Megan left home, I went to the nursing home to see her.I came across a

bicycle attached to the back of a wheelchair rolling out of the front entrance of the nursing home.The bike's unique design and the delight on the faces of the rider and the passenger stopped me.

Megan cried when she saw me.She said she didn't want to stay in the nursing home any more

and that she wanted to live with us at home.I took Megan out of the nursing home and bought

one the very next day.How happy she was to be with us again! We could now get outside for

fresh air, exercise and have a chance to be more involved in neighbourhood and community

activities.

     I invested (投资) all my money in buying this kind of wheelchair bike for the people who

needed them most.I call the wheelchair bike CAREBIKE.My aim is to permit people who have

disabilities and can't walk, as well as the people who care for them to have the chance to enjoy

the pleasure of a bike ride.

I'm extremely proud of what I've done.All my investment has its true reward when I hear a 100

yearold woman ending her CAREBIKE ride, laughing, or see a disabled man rolling down the

road with a smile on his face.Moments like these make it all worthwhile.

     My job now is to make the world aware of the CAREBIKE.My website provides pictures,

videos and the details about the bike.I will provide a CAREBIKE for anyone who really needs it.

1. Why did the author send his daughter to the nursing home?

A. Because the family was too poor to treat her.

B. Because he thought she would be cheered up there.

C. Because the nursing home could cure her illness.

D. Because he was tired of taking care of her at home.

2. The author stopped near the entrance of the nursing home for ________.

A. he saw an unusual wheelchair bike

B. he found his daughter was around there

C. he was stopped by a rider and a passenger

D. he recognized the passenger who was his friend

3. What was the purpose of the author investing his money in buying wheelchair bikes?

A. To earn money by selling them to the disabled people.

B. To hold a wheelchair bike race for the disabled in his community.

C. To offer a chance to disabled people to enjoy the pleasure of a bike ride.

D. To provide every disabled person in the nursing home with a wheelchair bike.

4. The underlined word "one" in Paragraph 3 refers to ______.

A. a CAREBIKE  

B. a bicycle

C. a wheelchair  

D. a gift