问题 多项选择题 案例分析题

坎地沙坦酯常用于治疗原发性高血压,其绝对生物利用度为15%,为了更好地发挥其降压作用,提高生物利用度,常利用固体分散体技术制备坎地沙坦酯速释和缓释固体分散体。以聚乙二醇-6000、泊洛沙姆-188为混合载体的速释型固体分散体与物理混合物对比,药物的溶出速率和溶出量明显提高,坎地沙坦酯生物利用度增加。

载体对固体分散体中药物溶出的促进作用是()

A.载体使药物提高可润湿性

B.载体促使药物分子聚集

C.载体对药物有抑晶性

D.载体保证了药物的高度分散性

E.载体对某些药物有氢键作用或络合作用

F.药物进入载体后改变了剂型

答案

参考答案:A, C, D, E

单项选择题
完形填空
Last week I went to a supermarket. After I   36  the bill and was passing through the door, the alarm suddenly started to ring. Suddenly, a young guard ran toward me and ordered me to   37  him. I felt so upset and   38 . He took me to a small room, but I was   39  frightened that I stopped at the door. Finding me   40  to enter the room, he shouted that I had to go into the room.
He closed the door. I thought he was going to hurt me. Suddenly, a   41  voice said in my ear, “Take out the things you've stolen!” “I stole nothing.” I said. “Do as I tell you. If we find them, you’ll be in trouble.” “There is nothing.” I answered. “I didn't take anything.” I said, taking everything out of my pockets and bag.
  42  this point, a guard came in and asked a salesgirl to   43  me.   44 , they found nothing.
But they didn't believe that I hadn't stolen anything. So the young guard ordered me to pass through the door alarm again.
I was   45  when it rang again. I felt   46  and burst into tears. I didn't know how to prove   47  I was innocent.
They made me go into the small room again.
“Take out the stolen things quickly,   48  we will dial 110.” They said.
“OK, call the police. I’ m not afraid.” I said   49  .
Suddenly, they   50  their tone. After a while, a salesgirl asked me to raise my feet. I did   51   she had told me. There was a label (标签) on the bottom of my shoe. That was it! That was the   52  thing that had brought me such great trouble. But it  53  my innocence.
After that, they   54  to me in the small room. But they should have apologized   55  , shouldn't they? A lot of people were there when I was taken away. What did they think of me?
小题1:
A.buyB.paidC.passedD.spent
小题2:
A.obeyB.begC.followD.listen to
小题3:
A.angryB.excitedC.happyD.puzzled
小题4:
A.veryB.muchC.suchD.so
小题5:
A.disagree B.unwillingC.voluntarilyD.willingly
小题6:
A.gentleB.coldC.soundD.polite
小题7:
A.OfB.InC.AtD.From
小题8:
A.look atB.watchC.examineD.keep
小题9:
A.Needless to sayB.So farC.On one handD.As a result of
小题10:
A.afraidB.frightenedC.shockedD.sad
小题11:
A.wrongedB.annoyingC.confusedD.unpleasant
小题12:
A.whatB.whetherC.thatD.how
小题13:
A.andB.butC.orD.so
小题14:
A.unhappilyB.forcefully C.terriblyD.widely
小题15:
A.changedB.raisedC.increasedD.closed
小题16:
A.likeB.asC.according toD.as if
小题17:
A.onlyB.lastC.veryD.just
小题18:
A.testedB.showedC.provedD.gave
小题19:
A.saidB.apologizedC.agreedD.promised
小题20:
A.loudlyB.togetherC.politelyD.in public