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患者男性，44岁，因“左侧丘脑胶质母细胞瘤术后4周行放疗”入院。2个月前患者出现头痛，无规律，持续进行性加重。颅脑MRI示：左侧丘脑、大脑脚见不规则异常信号影，增强扫描呈不均匀明显强化，占位效应明显。1个月前行左颞顶枕肿瘤切除术。术后病理示：胶质母细胞瘤。查体：意识清楚，言语流利，双瞳孔等大等圆，光反射（+），右侧肢体肌力5-级，左侧肢体肌力正常，神经病理征（-）。既往史：无外伤，无结核等慢性疾病史。无家族性疾病史。

患者手术后的治疗原则正确的是（）

A.手术后2～4周应尽快实施放化疗

B.推荐常规分次放疗并替莫唑胺（TMZ）75mg/m2同步化疗

C.可行单纯化疗

D.TMZ长周期辅助化疗有助于提高总生存率

E.同步放化疗后行最少6个周期的TMZ辅助化疗

F.MGMT基因启动子甲基化的患者替莫唑胺获益明显

答案

参考答案：A, B, D, E, F

选择题

若数列{an}对于任意的正整数n满足：an>0且anan+1=n+1，则称数列{an}为“积增数列”。已知“积增数列”{an}中，a1=1，数列{an2+an+12}的前n项和Sn，则对于任意的正整数n，有[ ]

A.Sn≤2n2+3

B.Sn≥n2+4n

C.Sn≤n2+4n

D.Sn≥n2+3n
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单项选择题

For the people who have never traveled across the Atlantic the voyage is a fantasy. But for the people who cross it frequently one crossing of the Atlantic is very much like another, and they do not make the voyage for the (56) of its interest. Most of us are quite happy when we feel (57) to go to bed and pleased when the journey (58) . On the first night this time I felt especially lazy and went to bed (59) earlier than usual. When I (60) my cabin, I was surprised (61) that I was to have a companion during my trip, which made me feel a little unhappy. I had expected (62) but there was a suitcase (63) mine in the opposite corner. I wondered who he could be and what he would be like. Soon afterwards he came in. He was the sort of man you might meet (64) , except that he was wearing (65) good clothes that I made up my mind that we would not (66) whoever he was and did not say (67) . As I had expected, he did not talk to me either but went to bed immediately.
I suppose I slept for several hours because when I woke up it was already the middle of the night. I felt cold but covered (68) as well as I could and tried to go back to sleep. Then I realized that a (69) was coming from the window opposite. I thought perhaps I had forgotten (70) the door, so I got up (71) the door but found it already locked from the inside. The cold air was coming from the window opposite. I crossed the room and (72) the moon shone through it on to the other bed. (73) there. It took me a minute or two to (74) the door myself. I realized that my companion (75) through the window into the sea.

A. a so B. soC. such aD. such
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