We haven't heard from Diana for a long time.What do you think ________ her?[ ]

A. has happened to  

B. to happen to

C. has happened on  

D. was happening to

男，75岁，发现高血压20年，因活动后感气促就诊。查体：血压160/86mmHg，脉率96次/分。UCG示左室向心性肥厚，左心房轻度增大，左心室内径和射血分数正常。请问下列药物中，哪些适用()

A．地高辛

B．培哚普利

C．维拉帕米

D．倍他洛克

E．以上均不适用