肝功能不全时，药物的药动学改变不正确的是（）

A.血浆中结合型药物减少，游离型药物增多

B.药物的半衰期缩短

C.药物的生物转化减慢

D.药物排泄减慢

E.药物分布容积增大

“Design of experiments” is a statistical method that helps （）.

A．determine how various elements of a system interrelate

B．identify which factors may influence specific variables of a product or process

C．establish a standard by which to measure performance

D．compare actual or planned project practices to those of other projects