Corruption is _______ problem in countries across the world, with developing countries often believed to be more serious, although there is no evidence to suggest this is _______case.

A．a; the

B．the; a

C．不填; the

D．a; a

厂房、设备、物料、文件和记录应当有（），并制定编制（）的操作规程，确保（）的唯一性。