腰椎间盘突出症的手术治疗指征为( )

A．有明显的神经压迫症状者

B．多次反复发作者

C．严格非手术治疗6个月以上效果不显著者

D．有急性腰扭伤者

E．感觉疼痛剧烈，不能行走

On the north of the bank _____ the Opera House, _____ was built two hundred years ago.

A．is lying; where

B．lies; what

C．lies; which

D．lying; that