Due to a constantly (66) environment, a poor understanding of the user’s needs and preferences, as well as a (67) of willingness to modify. (68) organizational structures and decision models, the full economic potential of Web Information Systems (WIS) has not been realized by now. The data object types of the (69) meta model, the Extended World Wide Web Design Technique (eW3DT), provide hypertext designers (70) a conceptual, user-centric framework and graphical notation for the construction of both, (71) and customized models, during the software development (72) of commercial WIS. A reference model as a normative concept represents an abstraction of a (73) company, its functional units, or its Web Information System and is intended to streamline the design and implementation of complex applications at (74) costs. As precondition for pursuing a partial globalization strategy,eW3DT (75) between technical and content-specific responsibilities for designing, implementing, and maintaining WIS.

（70）（）

A.of

B.in

C.to

D.with

关于食管癌的淋巴转移特点，下列错误的是（）。

A.仅次于血行转移的转移途径

B.上段食管癌常转移至锁骨上及颈淋巴结

C.中下段多转移至气管旁、贲门及胃左动脉旁淋巴结

D.各段均可向上或向下方的淋巴结转移

E.约1／4病例的淋巴结转移是跳跃式