问题
单项选择题
关于肝功能不全时药动学/药效学改变的说法中,正确的是
A.血浆中结合型药物增多,游离型药物减少
B.药物代谢减慢,清除率上升,半衰期缩短
C.经胆汁分泌排泄的药物排泄减慢
D.药物分布容积减小
E.经肝代谢药物的药效与毒副作用降低
答案
参考答案:C
解析:肝功不全时,白蛋白制造能力降低,游离药物增多;药酶活性降低,代谢减慢,并导致胆汁分泌排泄障碍,伴有水肿时增大了药物分布容积。
关于肝功能不全时药动学/药效学改变的说法中,正确的是
A.血浆中结合型药物增多,游离型药物减少
B.药物代谢减慢,清除率上升,半衰期缩短
C.经胆汁分泌排泄的药物排泄减慢
D.药物分布容积减小
E.经肝代谢药物的药效与毒副作用降低
参考答案:C
解析:肝功不全时,白蛋白制造能力降低,游离药物增多;药酶活性降低,代谢减慢,并导致胆汁分泌排泄障碍,伴有水肿时增大了药物分布容积。
小题1:Ghostwritten work in “CONTEST RULES” might be ________. a. written by someone other than the author b. science fiction difficult to understand c. a long essay in a very strange writing style d. full of citations from other writers 小题2:To enter the writing contest, one ________. a. has to pay a fee b. must submit work by January 1, 2008 c. needs an eye-catching title for his word document d. can submit any form or style of writing but a poem 小题3:Which of the following is NOT TRUE? a. The final results will come out on December 31, 2008. b. All entries must be emailed to contest2008@adminmaven.com. c. One can not add a note to a 1,500-word essay for the contest. d. the winning entries will be edited and published. |