问题 单项选择题

关于肝功能不全时药动学/药效学改变的说法中,正确的是

A.血浆中结合型药物增多,游离型药物减少

B.药物代谢减慢,清除率上升,半衰期缩短

C.经胆汁分泌排泄的药物排泄减慢

D.药物分布容积减小

E.经肝代谢药物的药效与毒副作用降低

答案

参考答案:C

解析:肝功不全时,白蛋白制造能力降低,游离药物增多;药酶活性降低,代谢减慢,并导致胆汁分泌排泄障碍,伴有水肿时增大了药物分布容积。

选择题
阅读理解

CONTEST RULES
·Entries may be submitted(上交) no earlier than January 1, 2008, and will not be accepted until three winners are identified or December 31, 2008 whichever comes first.
·There is no cost to enter.
·Entrants must be at least 18 years of age.
·Any form and style is acceptable for this competition: fiction, observational essay, humor, etc. poetry is not acceptable.
·Total length of writing must be 500-1500 words, including any necessary notes or citations.
·Writing must be original, never before published, and entirely the work and property of the person who submits it. Ghostwritten is not acceptable.
PRIZES
Winners will receive
·$50 cash
·Professional editing of their winning entries.
·Publication of their entries in Word-wise.
·Recognition via press releases announcing the winning entries and introducing the authors.
HOW TO ENTER
·Save your completed writing as a Word, WordPerfect, Open Document, or plain text file.
·Title the file with your first and last name. For example, Elton Smith would title his Word document thus: elton-smith.doc.
·Email the file as an attachment to contest2008@adminmaven.com. Use the subject line “Work-wise Writing Contest” to avoid being removed to the span bin.
·Entries submitted before the opening date of January1, 2008, will be deleted. Once the contest closes, further entries will be deleted.
 
小题1:Ghostwritten work in “CONTEST RULES” might be ________.
a. written by someone other than the author
b. science fiction difficult to understand
c. a long essay in a very strange writing style
d. full of citations from other writers
小题2:To enter the writing contest, one ________.
a. has to pay a fee
b. must submit work by January 1, 2008
c. needs an eye-catching title for his word document
d. can submit any form or style of writing but a poem
小题3:Which of the following is NOT TRUE?
a. The final results will come out on December 31, 2008.
b. All entries must be emailed to contest2008@adminmaven.com.
c. One can not add a note to a 1,500-word essay for the contest.
d. the winning entries will be edited and published.