—I think it is ______ great pleasure to work with you.

—Me too. What’s more, what we’re doing will make ____ big difference to the lives of poor families.

A．a; a

B．a; 不填

C．不填; the

D．the; an

功能神经外科手术的适应证是（）

A.保守治疗效果较差的帕金森病

B.保守治疗效果较差的脑梗死

C.保守治疗效果较差的痴呆

D.保守治疗效果较差的酗酒

E.合并脑萎缩