患者，女性，54岁，近1年来体重明显增加，伴疲劳，厌食，便秘；血清TSH80mU/L（正常0.6～4mU/L），双手非凹陷性水肿。甲状腺Ⅱ度肿大，表面不平，呈橡皮样韧硬。

根据患者临床表现，最先考虑的诊断是（）

A.甲状腺功能减退症

B.急进性肾炎

C.肥胖症

D.右心衰竭

E.更年期综合征

OOO Festival organised a day of traditional folk music to take place on a public holiday. It entered into a contract with a popular folk music group to play at the festival as the main attraction. As the group was in p demand, OOO Festival paid 50% of the group’s fee in advance to secure the booking. It entered into a further contract with OOO Sweep to remove litter and clean the venue after the event had fi nished.One day before the event, the folk music group contacted OOO Festival to inform it that the group’s most important musician had been taken ill suddenly, but a replacement group had been engaged to take the group’s place.Due to an administrative error, OOO Sweep found that they had insuffi cient workers to perform the cleaning duties after the event, but hired another cleaning company to carry out this work.Required:

(b) Explain whether OOO Festival can claim a refund of the 50% deposit paid to the group that was unable to perform due to the illness of the musician. (3 marks)