男，32岁。呼吸困难3～4年，查体：负性心尖搏动，心尖区舒张期杂音及开瓣音。该患者负性心尖搏动说明（）

A.左室轻度增大

B.左室明显增大

C.右室轻度增大

D.右室明显增大

E.左右室皆增大

—Do you know ______ last night?  

—Sorry , I don't know. But I  think he should go to bed early

because he will have an English exam this afternoon.  [ ]

A. when he goes to bed    

B. when he went to bed    

C. when did he go to bed    

D. when does he go to bed