慢性粒细胞白血病发生急性左上腹（外侧）剧痛，首先考虑的诊断是（）

A.急性胰腺炎

B.胃溃疡穿孔

C.降结肠炎

D.脾栓塞

E.左肾结石

With a lot of difficult problems（）,the manager felt worried all the time.

A. settled

B. to be settled

C. settling

D. to settle