患者男，66岁，因“上腹部疼痛不适1周”来诊。患骨关节炎，口服双氯芬酸75mg，2次/d，曲马多50mg，2次/d，唑来膦酸，剂量不详。

关于非甾体消炎药，叙述正确的是（）。

A.使用这类药物就意味着高心血管并发症

B.除对乙酰氨基酚外，都是高血浆蛋白结合率，因而不能同时使用2种非甾体消炎药

C.环氧化酶-1和环氧化酶-2抑制剂都是作用于外周的镇痛药

D.这些药物都有耐受性，使用中要增加剂量

E.所有环氧化酶-2抑制药都有同样的副作用

Optimism is the art of always seeing the glass half full (1) half empty, finding something positive in even the most (2) of situations and last but not least the ability to expect the best even if the chances are (3) . It enables you to try new things, deal with failure as a learning experience (4) a stopping point. In general optimism gives you a reason to live. The world would be a better place if it was full of optimism, (5) unfortunately the trend in today’s youth is (6) the opposite way. Today it is (7) to be pessimistic. One could spend hours discussing how we arrived at this point, (8) our youth refuses to smell the roses and instead prefers to (9) themselves on their own pessimistic (10) .

Optimism is not an (11) gift but rather a learned behavior (12) . Like most behaviors optimism is best learned by watching examples, (13) you. The first step in creating a generation of people with a positive outlook on life, is to (14) life on the bright side yourself. (15) it would be wrong to (16) your child from all negativity, it is important that you are not the (17) of doubts and worries. Finding something positive in a negative situation needs to be (18) Show how to make the best of things by always (19) the positive, by encouraging your child after a(n) (20) and by explaining over and over that failure is just a part of progress.

12（）

A.pattern

B.format

C.capacity

D.mold