______ attractions you are planning to visit in that island country, you'd better book your hotel _____

because the hotels are always full in the tourist seasons. [ ]

A. Whatever; in the advance                

B. Wherever; before hand  

C. Whichever; in advance                  

D. Whosever; before hand

以下大疱病中具有显著瘙痒的是（）

A.寻常型天疱疮

B.大疱性类天疱疮

C.家族性慢性良性天疱疮

D.药物诱导型天疱疮

E.疱疹样天疱疮