医疗机构施行特殊治疗时（）

A.可以由经治医生决定施行

B.可以由本科在科主任主持下讨论决定施行

C.由医院决定施行

D.可以征求患者意见

E.必须征得患者同意

How did it _____ that the car fell off the bridge into the river? [ ]

A. come out

B. come about

C. come across

D. come up