— Could you tell me how the sea sand comes about? 

— Sea waves dash against the rock. In this way, the sea sand ___. [ ]

A. comes into use

B. comes into office

C. comes into effect

D. comes into being

男性，30岁，逐渐出现贫血，黄疸，脾肋下3cm，HGB90g／L，白细胞、血小板正常，网织红细胞5%，红细胞脆性试验0．7%，血片中见球形细胞，Combs试验阴性。最有效的治疗是（）

A.抗生素治疗

B.糖皮质激素治疗

C.输血

D.骨髓移植

E.切除脾